A DHS TED challenge is conducting independent operational evaluations of cutting-edge Chemical, Biological, Radiological, Nuclear, and Explosive (CBRNE+) threat and hazard detection and interdiction technologies and programs, which are critical to mission support for deterring and preventing terrorism and securing the nation’s borders. The hazardous nature of CBRNE+ agents preclude rigorous performance testing using active threat surrogates within the intended operational environment. The span of assessment effort typically addresses prohibited, hazardous, illicit, and contraband material and items (e.g., weaponry, synthetic opioids, counterfeit goods, and currency). The solutions to CBRNE+ threats often cross component and departmental boundaries. The DHS TED requires the development of innovative, tailored, and defensible T&E strategies; and the integration of multiple data sources, test methodologies, and capabilities to support efficient and effective T&E for CBRNE+ major acquisition programs and other initiatives. The DHS T&E CoBP independent subject matter expert reach back capability for planning, execution, analysis, and reporting of T&E efforts is critical in supporting informed programmatic decisions by senior leadership.